The National Institute for Health and Medical Research (Inserm) has announced that it has taken a step forward in developing an effective vaccine against allergic asthma. Attempts made in mice to elicit antibodies to human proteins have been successful.
The researchers are now contemplating the next step: moving into human clinical trials. The prospect of a vaccine is a hope for millions of allergic asthma sufferers, especially those who suffer from severe forms. In France, “severe asthma”remembers Inserm, “directly linked to over 60,000 hospitalizations and nearly 900 deaths a year”.
Overproduction of antibodies
The vaccine was developed jointly by scientists from Inserm, CNRS, the Pasteur Institute, the University of Toulouse III, and the French company Neovacs. In their latest study, published in the specialized journal Allergy, the researchers demonstrate the effectiveness of their vaccine in producing antibodies that can “neutralize key human immune proteins that cause allergic asthma.”.
These proteins, the cytokines IL-4 and IL-13, along with antibodies called immunoglobulin E, are produced by the body in response to exposure to house dust mites and other allergens. This overproduction phenomenon, as explained in the Inserm press release, results in “airway hyperreactivity, mucus overproduction, and eosinophilia (too high levels of white blood cells called eosinophils in the airways)”.
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About two million French sufferers of allergic asthma mostly receive corticosteroids delivered via inhalers. But for cases of severe allergic asthma, this answer is not enough. Patients are then treated with therapeutic monoclonal antibodies, drugs “expensive and requires patients to inject for years, even a lifetime”.
The vaccine, called Kinoid®, is their hope for a simpler and less expensive treatment. And not only in France, as more than 150 million people worldwide suffer from allergic asthma. According to promising preclinical studies, the vaccine may also prevent other allergic conditions such as atopic dermatitis and food allergies.
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Source: TF1